¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ·

The Muscle Enzyme Histochemistry Lab at ¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ· Children’s, based in Wilmington, Delaware, specializes in diagnostic analysis of muscle tissue using enzyme‑specific staining techniques. Muscle biopsy is a key tool in evaluating neuromuscular disorders and is frequently used in research exploring the effects of exercise on muscles.</p>\r\n<p>Our work supports clinical teams during critical stages of a child’s diagnostic journey. Clearer, more precise findings help reduce uncertainty for families and guide decisions about next steps in treatment and long‑term care.</p>\r\n"}} id=text-232279b75c class=cmp-text>

The Muscle Enzyme Histochemistry Lab at ¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ· Children’s, based in Wilmington, Delaware, specializes in diagnostic analysis of muscle tissue using enzyme‑specific staining techniques. Muscle biopsy is a key tool in evaluating neuromuscular disorders and is frequently used in research exploring the effects of exercise on muscles.

Our work supports clinical teams during critical stages of a child’s diagnostic journey. Clearer, more precise findings help reduce uncertainty for families and guide decisions about next steps in treatment and long‑term care.

Our lab is located on the&nbsp;¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ· Children’s Hospital, Delaware campus. The facility supports specialized diagnostic testing using advanced histology and microscopy equipment, including:</p>\r\n<ul>\r\n<li><b>Thermo cryostat</b>&nbsp;for frozen muscle sectioning.</li>\r\n<li><b>Olympus BX40 microscope</b>&nbsp;for detailed tissue evaluation.</li>\r\n<li><b>Mettler balance and Accumet pH meter</b>&nbsp;to support controlled staining processes.</li>\r\n</ul>\r\n"}} id=text-39420b5da2 class=cmp-text>

Our lab is located on theÌý¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ· Children’s Hospital, Delaware campus. The facility supports specialized diagnostic testing using advanced histology and microscopy equipment, including:

• Thermo cryostatÌýfor frozen muscle sectioning.
• Olympus BX40 microscopeÌýfor detailed tissue evaluation.
• Mettler balance and Accumet pH meterÌýto support controlled staining processes.

We’re a Clinical Laboratory Improvement Amendments (CLIA)-certified lab. All testing follows established laboratory protocols designed to ensure accuracy and reproducibility. These standards are essential when evaluating rare or complex neuromuscular conditions.</p>\r\n"}} id=text-b1ed023417 class=cmp-text>

We’re a Clinical Laboratory Improvement Amendments (CLIA)-certified lab. All testing follows established laboratory protocols designed to ensure accuracy and reproducibility. These standards are essential when evaluating rare or complex neuromuscular conditions.

Our labs contribute to research that informs pediatric care, working in alignment with research centers and focused areas of scientific study at ¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ·.</p>\r\n"}} id=text-71866d1b44 class=cmp-text>

Our labs contribute to research that informs pediatric care, working in alignment with research centers and focused areas of scientific study at ¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾Ã¾«Æ·.

The Muscle Enzyme Histochemistry Lab provides specialized analysis of pediatric muscle tissue to support the diagnosis of neuromuscular disorders.</p>\r\n<p>Enzyme-specific staining reveals differences in muscle fiber type, metabolic activity, and structural integrity. Findings are interpreted alongside clinical history and other diagnostic studies to inform care decisions.</p>\r\n"}} id=text-7cb8a91b18 class=cmp-text>

The Muscle Enzyme Histochemistry Lab provides specialized analysis of pediatric muscle tissue to support the diagnosis of neuromuscular disorders.

Enzyme-specific staining reveals differences in muscle fiber type, metabolic activity, and structural integrity. Findings are interpreted alongside clinical history and other diagnostic studies to inform care decisions.

We offer a focused set of stains commonly used in neuromuscular evaluation. Stains are selected based on the clinical question and specimen characteristics. All testing follows standardized laboratory protocols.</p>\r\n<h3><b>Routine &amp; Structural Assessment</b></h3>\r\n<ul>\r\n<li>Hematoxylin &amp; Eosin (H&amp;E)</li>\r\n<li>Trichrome</li>\r\n<li>Periodic Acid-Schiff (PAS)</li>\r\n<li>Oil Red O</li>\r\n</ul>\r\n<h3><b>Fiber Typing &amp; Enzyme Activity</b></h3>\r\n<ul>\r\n<li>ATPase (pH 10.2)</li>\r\n<li>ATPase (pH 4.6)</li>\r\n<li>NADH-TR</li>\r\n</ul>\r\n<h3><b>Metabolic &amp; Mitochondrial Evaluation</b></h3>\r\n<ul>\r\n<li>Succinate Dehydrogenase (SDH)</li>\r\n<li>Cytochrome C Oxidase (COX)</li>\r\n</ul>\r\n<h3><b>Additional Enzymatic Markers</b></h3>\r\n<ul>\r\n<li>Alkaline Phosphatase</li>\r\n<li>Neuron-Specific Enolase (NSE)</li>\r\n</ul>\r\n"}} id=text-e2097f4780 class=cmp-text>

We offer a focused set of stains commonly used in neuromuscular evaluation. Stains are selected based on the clinical question and specimen characteristics. All testing follows standardized laboratory protocols.

Routine & Structural Assessment

• Hematoxylin & Eosin (H&E)
• Trichrome
• Periodic Acid-Schiff (PAS)
• Oil Red O

Fiber Typing & Enzyme Activity

• ATPase (pH 10.2)
• ATPase (pH 4.6)
• NADH-TR

Metabolic & Mitochondrial Evaluation

• Succinate Dehydrogenase (SDH)
• Cytochrome C Oxidase (COX)

Additional Enzymatic Markers

• Alkaline Phosphatase
• Neuron-Specific Enolase (NSE)